SISTAM2015

SISTAM2015-3 en baja

ORGANIZING COMMITTEE

  • Roger Davis   – University of Massachusetts, Worcester, MA, USA
  • J. Silvio Gutkind – NIDCR, NIH, Bethesda, MD, USA
  • Lucio Castilla – University of Massachusetts, Worcester, MA, USA
  • Adali Pecci – Universidad de Buenos Aires,  Argentina
  • Omar A. Coso – Universidad de Buenos Aires.  Argentina

SCIENTIFIC COMMITTEE

  • Lutz Birnbaumer – Universidad Nacional de San Martín – Argentina
  • José Luis Bocco – Universidad de Córdoba – Argentina
  • Edith Kordon – Universidad de Buenos Aires – Argentina
  • Enrique Mesri – University of Miami – USA
  • Uri Saragovi – Mc Gill University – Canada

SPEAKERS

Keynote Lectures: 

  • Mark Lemmon – University of Pennsylvania Perelman School of Medicine, USA
  • Joseph Schlessinger – Yale University School of Medicine, New Haven, USA
  • Speakers:
  • Roger Davis – University of Massachusetts Medical School, USA
  • Guadalupe Sabio – Centro Nacional de Investigaciones Cardiovasculares Carlos III, Spain
  • Kathryn Ferguson – University of Pennsylvania, Perelman School of Medicine, USA
  •  Nicolás Plachta – EMBL  Australia, Monash University, Australia
  • Onno Meijer – Leiden University Medical Center, The Netherlands
  • Silvio Gutkind – NIDCR, NIH, USA
  • Ghosh Sourav – Department of Neurology, Yale University School of Medicine, USA
  • Piero Crespo – Instituto de Biomedicina y Biotecnología de Cantabria (CSIC), Universidad de Cantabria, Spain
  •  Xosé Bustelo – Centro de Investigación del Cáncer, CSIC, University of Salamanca, Spain
  • George Thomas – Catalonian Institute of Oncology/IDIBELL, Spain
  • Sara Kozma – Catalonian Institute of Oncology/IDIBELL, Spain
  • Gerhard M. Christofori – Department of Biomedicine, University of Basel, Switzerland
  • Michelle Kelliher – University of Massachusetts Medical School, USA
  • Gabriel Rabinovich – IBYME, CONICET, Argentina
  • Carla Rothlin – Yale University, School of Medicine, USA
  • Uri Saragovi – Lady Davis Institute-Jewish General Hospital, McGill University, Canada
  • David Guertin – University of Massachusetts, Medical School, USA
  • Stephen Nimer – Sylvester Comprehensive Cancer Center and University of Miami Miller School of Medicine, USA
  • Marla Berry – University of Hawaii, John A. Burns School of Medicine, USA
  • Lucio Castilla – University of Massachusetts Medical School, USA
  • Alberto Kornblihtt – IFIBYNE, CONICET, University of Buenos Aires, Argentina
  • Lutz Birnbaumer – Universidad Nacional de San Martin, Argentina

PROGRAM

Wednesday, April 1st

3:00 pm                                      Registration opens at the main Lobby

7:00 pm 8:00 pm                Opening Statements by the organizers followed by the Opening Keynote Lecture:  Mark Lemmon

University of Pennsylvania Perelman School of Medicine, USA

Diversity of Receptor Tyrosine Kinase Signaling Mechanisms

8:30 pm                               Welcome Reception

 

Thursday, April 2nd

7:00 am – 9:00 am             Breakfast

9:00 am – 10:50 am           Session # 1

9:00 am – 9:45am                               Speaker # 1: Roger Davis

University of Massachusetts Medical School, USA.

Metabolic Stress Signaling Mediated by JNK

 9:45 am – 10:30 am           Speaker # 2: Guadalupe Sabio

Centro Nacional de Investigaciones Cardiovasculares Carlos III, Spain

 The Role of p38g and d in Heart Growth

 10:30am – 10: 50am           Short Talk # 1: Fabio L. Forti

Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Brazil

 DUSP3 Affects Proliferation and Differentiation of Neuroblastoma Cells through ERK1/2 Via

 10:50 am – 11:20 am         Coffee Break

 11:20 am – 12:45 pmSession # 2

11:20 am – 12:05 am         Speaker # 3: Kathryn Ferguson

University of Pennsylvania, Perelman School of Medicine, USA

Regulation of the Tie Family of Receptor Tyrosine Kinases

 12:05 am – 12:25 pm         Short Talk # 2: Gustavo Paratcha

Division of Molecular and Cellular Neuroscience. IBCN-“Prof. E. De Robertis”- CONICET–UBA, Argentina

 The Leucine-Rich Repeat Transmembrane Protein LRIG1 Restricts Hippocampal Dendrite Complexity by Modulating Neurotrophin-Induce TRKB Signaling

12:25 pm – 12:45 pm         Short Talk # 3: Fernanda Ledda

 Division of Molecular and Cellular Neuroscience. IBCN-“Prof. E. De Robertis”- CONICET–UBA, Argentina

 PEA3 Transcription Factor Family Member, ETV4 and ETV5, Mediate NeuriteOutgrowth in Response to Neurotrophins

 1:00 pm – 3:00 pm             Lunch

 3:00 pm – 5:10 pm             Session # 3

3:00 pm – 3:45 pm              Speaker # 4: Nicolás Plachta

EMBL  Australia, Monash University, Australia

Imaging the Signals that Control Cell Fate in Living Mouse Embryos

3:45 pm – 4:05 pm              Short Talk # 4: Martín Stortz

IFIBYNE-CONICET, University of Buenos Aires, Argentina.

Intracellular Dynamics of the Glucocorticoid Receptor and its Co-Regulator TIF2/GRIP1

4:05 pm – 4:50 pm              Speaker # 5: Onno Meijer

Leiden University Medical Center, The Netherlands

The Good and Bad of Stress: Using Different Signaling Modes of the Glucocorticoid Receptors to Understand and Target Stress-Related Disease

4:50 pm – 5:10 pm              Short Talk # 5: Marina Simian

Instituto de Oncología “Angel H. Roffo”, Argentina

 The Extracellular Matrix Determines Estrogen Receptor’s Longevity by an Endosomal-Recycling Pathway: Implications for endrocrineResistance in Breast Cancer

 5:10 pm – 5:40 pm             Coffee Break

5:40 pm – 7:50 pm             Session # 4:

5:40 pm – 6:25 pm              Speaker # 6: Silvio Gutkind

NIDCR, NIH, USA

A Novel Gas-PKA Tumor Suppressor Pathway Restraining YAP1 and GLI in Skin Stem Cells

6:25 pm – 6:45 pm              Short Talk # 6: Susana Silberstein

Instituto de Investigación en Biomedicina de Buenos Aires – CONICET – PartnerInstitute of the Max Planck Society. Departamento de Fisiología y Biología Molecular y Celular, FCEN-UBA, Argentina

 Two Cyclic AMP Sources Are Critical for Signaling of the GPCR CRHR1

 6:45 pm – 7:30 pm              Speaker # 7: Ghosh Sourav

Department of Neurology, Yale University School of Medicine, USA

 Metamorphosisof a Developmental Signaling Pathway in Cancer

7:30 pm – 7:50 pm              Short Talk # 7: Deborah Schechtman

Departamento de Bioquímica Instituto de Química – Universidade de São Paulo, Brazil

 Recognition of Structural Consensus Sites by Protein Kinases

 8:00 pm – 9:15 pm             Dinner

 9:15 pm – onwards           First Poster Session

 

Friday, April 3rd

 7:00 am – 9:00 am             Breakfast

 9:00 am – 10:30 am           Session # 5

9:00 am – 9:45 am              Speaker # 8: Piero Crespo 

Instituto de Biomedicina y Biotecnología de Cantabria (CSIC), Universidad de Cantabria, Spain.

 Ras Signals from the Golgi Complex Induce Apoptosis

9:45 am – 10:30 am           Speaker # 9: Xosé Bustelo

Centro de Investigación del Cáncer, CSIC, University of Salamanca, Spain

An Unexpected Tumor Suppressor-Like Role for the VAV1 Proto-Oncogene

10:30 am – 11:00 am         Coffee Break

 11:00 am – onwards          Meet the speakers and recreation I

 1:30 pm – 3:00 pm             Lunch

 3:00 pm – 4:50 pm             Session # 6

3:00 pm – 3:45 pm              Speaker # 10: George Thomas

Catalonian Institute of Oncology/IDIBELL, Spain

mTORC1, Ribosome Biogenesis, Cell Cycle Checkpoints and Cancer Progression

3:45 pm – 4:30 pm              Speaker # 11: Sara Kozma

Catalonian Institute of Oncology/IDIBELL, Spain

 Inhibition of mTORC1 and Autophagy in Hepatocellular Carcinoma

4:30 pm – 4:50 pm              Short Talk # 8: Stéfano Cirigliano

Institute of Oncology “Ángel H. Roffo”, Argentina

CIGB-300 Treatment in Lung Cancer Cells: Effect on NF-κB Inhibition and Penetration in 3D Spheroids

4:50 pm – 5:20 pm             Coffee Break

5:20 pm – 7:30 pm             Session # 7

5:20 pm – 6:05 pm             Speaker # 12: Gerhard M. Christofori

Department of Biomedicine, University of Basel, Switzerland

Complex Transcriptional Control of Epithelial-Mesenchymal Transition and Cancer Metastasis

6:05 pm – 6:25 pm             Short Talk # 9: Johanna Tocci

IFIBYNE-CONICET, University of Buenos Aires, Argentina

  RSPO3 Is a Glycoprotein Secreted by Mammary Basal Cells that Induces Canonical WNT-Pathway Activation, EMT and Aggressive Tumorigenic Behavior in vivo

6:25 pm – 7:10 pm             Speaker # 13 : Michelle Kelliher

University of Massachusetts Medical School, USA

Regulation RIPK1 Signaling in Cell Death and Inflammation

7:10 pm – 7:30 pm             Short Talk # 10: María Victoria Goddio

 IFIBYNE-CONICET, University of Buenos Aires, Argentina

 The AU-RICH mRNA Binding Protein Tristetraprolin (TTP) Contributes to Lactatin Maintenance in the Mouse Mammary Gland

 7:30 pm – 7:50 pm             Short Talk # 11: Nathalie Cella

Instituto de Ciências Biomédicas, Departamento de Biologia Celular e do Desenvolvimento, Universidade de São Paulo, Brazil

 Maspin Subcellular Localization During the Development of the Mouse Mammary Gland

 8:00 pm – 9:15 pm             Dinner

 9:15 pm – onwards           Second Poster Session

 

Saturday, April 4th

 

7:00 am – 8:40 am             Breakfast

8:40 am – 10:40 am           Session # 7:

8:40 am – 9:25 am              Speaker # 14: Gabriel Rabinovich

IBYME, CONICET, Argentina

Signaling by Lectin-Glycan Complexes in Immunity and Angiogenesis

9:25 am – 10:10 am           Speaker # 15: Carla Rothlin

Yale University, School of Medicine, USA

Immunobiology of TAM Receptor Tyrosine Kinases

10:10 am – 10:30 am         Short Talk # 12: Andrés Martín Toscani

IQUIBICEN, UBA-CONICET, Argentina

 Play in Context: Extracellular Matrix Receptors Modulating HRG Signaling in Breast Cancer Cells

 10:30 am – 11:00 am         Coffee Break

 11:00 am – 5:00 pm           Meet  the speakers and recreation II

 6:00 pm – 8:10 pm             Session # 8:

6:00 pm – 6:45 pm              Speaker # 16: Uri Saragovi

Lady Davis Institute-Jewish General Hospital, McGill University, Canada

Academic Translational Medicine: from Target Discovery and Validation, to Experimental Therapeutics, to the Clinic

 6:45pm – 7:05 pm                               Short Talk # 13: Fernando R. Benavent Acero

Laboratory of Molecular Oncology, UNQ, Argentina

 Antitumor Effect of CIGB-300 Peptide, a Protein Kinase CK2 Inhibitor in Preclinical Lung Cancer Models

7:05 pm – 7:50 pm              Speaker # 17: David Guertin

University of Massachusetts, Medical School, USA.

mTORC2 Signaling in Adipocyte Metabolism andInsulin Resistance

7:50 pm – 8:10 pm               Short Talk # 14: María Elisa Mercau

Department of Human Biochemistry, FMed-UBA, CEFYBO-CONICET, Argentina

 Autophagy and Oxidative Stress Contribute to the Functional Remodeling of the Anterior Pituitary Gland in Diet-Induced Insulin Resistance

 8:15 pm – 9:15 pm             Dinner

 9:15 pm – onwards           Third Poster Session

 

Sunday, April 5th

 

7:00 am – 9:00 am             Breakfast

 

9:45 am – 10:30 am            Sepaker # 18: Stephen Nimer

Sylvester Comprehensive Cancer Center and University of Miami Miller School of Medicine, USA

The Role of Arginine Methyltransferases in Normal and Malignant Hematopoiesis

10:30 am – 10:50 am          Short Talk # 15: Enrique A. Mesri

Viral Oncology Program, Sylvester Cancer Center; Miami Center for AIDS Research, Dept. of Microbiology and Immunology, USA

PDGF Receptor-α as Oncogenesis Driver in Kaposi’s Sarcoma: Insights into Kaposi’s Sarcoma Herpes Virus Pathology and into Targeted Therapies for AIDS-Associated Kaposi’s Sarcoma

 10:50 am – 11:20 am         Coffee Break

  11:20 am – 12:45 pm         Session # 10

11:20 am – 12:05 pm         Speaker #19: Marla Berry

University of Hawaii, John A. Burns School of Medicine, USA

Targeted Deletion of Selenium Transport and Recycling pathways in Mice: Neurological and Metabolic Consequences

12:05 pm – 12:25 pm         Short Talk # 16: Gianina Demarchi

Centro de Investigaciones Básicas y Aplicadas, CITNOBA (CONICET-UNNOBA), Argentina

WNT/β-Catenin Pathway Activation in Murine Models of Prolactinomas

 1:00 pm – 3:00 pm             Lunch

3:00 pm – 4:45 pm             Session # 11:

3:00 pm – 3:45 pm              Speaker # 21: Lucio Castilla,

University of Massachusetts Medical School, USA.

3:45 pm – 4:05 pm               Short Talk # 17: Matias Blaustein

IFIBYNE-CONICET, DFBMC-FCEyN-UBA, Argentina

Spatio-Temporal Cell Signaling Dynamics: Towards and AKT Fingerprint

 4:05 pm – 4:25 pm               Short Talk # 18: Santiago Rodriguez Segui

IFIBYNE-CONICET, DFBMC-FCEyN-UBA, Argentina

 TEAD and YAP Regulate the Enhancer Network of Human Embryonic Pancreatic Progenitors

 4:25 pm – 4:45 pm              Short Talk # 19: Martin Abba

CINIBA, Faculty of Medical Sciences, UNLP, Argentina

 The Molecular Landscape of Breast Ductal Carcinoma in situ

4:45 pm – 5:15 pm             Coffee Break

 5:15 pm – 6:45 pm             Session # 12:

5:15 pm – 6:00 pm              Speaker # 22: Alberto Kornblihtt

IFIBYNE, CONICET, University of Buenos Aires, Argentina

Chromatin, RNA Polymerase II Elongation and Alternative Splicing

6:00 pm – 6:45 pm              Speaker # 23: Lutz Birnbaumer

Universidad Nacional de San Martin, Argentina

On the Discovery of a Role of GTP and G Proteins in Signal Transduction: Personal Recollections 40Years Later

 7:30 pm – 8:30 pm             Keynote Lecture:

 Joseph Schlessinger

Yale University School of Medicine, New Haven, USA

Cell Signaling by Receptor Tyrosine Kinases; from Basic Principles to Cancer Therapy

 8:40 pm:                               Closing Remarks

9:30 pm- onwards             Traditional Barbecue – ASADO – Jitterbug Dancing and Chacarera

Monday, April 6th

 7:00 am – 8:30 am              Farewell Breakfast and Meeting Adjourns

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