Scientific Background

Signal Transduction studies the molecular, biochemical and biological responses that all living cells develop to adapt to changes in their environment, including changes in protein conformation, enzyme activity and gene expression regulation, which ultimately results in morphological changes, cell migration, proliferation, differentiation or death. In health, these mechanisms are tightly regulated and become responsible for the normal growth pattern of individual cells and the development of multicellular organisms as ours. In contrast, deregulation of signal transduction pathways leads to some of the most prevalent diseases and pathologies, ranging from metabolic, cardiovascular, and immune diseases to cancer.

The promotion of exchange of ideas, discussion of emerging results, and training of junior scientists around the globe is desperately needed to achieve the molecular understanding of normal physiological processes and their dysregulation in a myriad of disease conditions, hence enabling the development of improved therapeutic strategies.